PHARMACOKINETICS AND TISSUE DISTRIBUTION OF IOMEPROL IN ANIMALS

The pharmacokinetics of iomeprol, a new triiodinated nonionic radiogra phic contrast agent, has been studied in rats, rabbits and dogs. Follo wing intravenous administration, iomeprol did not bind measurably to p lasma proteins and was rapidly excreted in unchanged form, mostly thro ugh the kidneys. The compound was rapidly distributed to the plasma an d thence to the extracellular spaces. Iomeprol did not accumulate in s pecific organs or tissues except for those involved in its elimination , i.e. the kidneys and the liver. However, 24 h after administration, less than 1% of the injected dose remained in the tissues. The overall profile was very similar to the published profiles of other radiograp hic contrast agents used in uroangiography.