The pharmacokinetics of iomeprol, a new triiodinated nonionic radiogra
phic contrast agent, has been studied in rats, rabbits and dogs. Follo
wing intravenous administration, iomeprol did not bind measurably to p
lasma proteins and was rapidly excreted in unchanged form, mostly thro
ugh the kidneys. The compound was rapidly distributed to the plasma an
d thence to the extracellular spaces. Iomeprol did not accumulate in s
pecific organs or tissues except for those involved in its elimination
, i.e. the kidneys and the liver. However, 24 h after administration,
less than 1% of the injected dose remained in the tissues. The overall
profile was very similar to the published profiles of other radiograp
hic contrast agents used in uroangiography.