TOXICOLOGICAL SAFETY ASSESSMENT OF IOMEPROL, A NEW X-RAY CONTRAST AGENT

Citation
A. Morisetti et al., TOXICOLOGICAL SAFETY ASSESSMENT OF IOMEPROL, A NEW X-RAY CONTRAST AGENT, European journal of radiology, 18, 1994, pp. 190000021-190000031
Citations number
NO
Categorie Soggetti
Radiology,Nuclear Medicine & Medical Imaging
ISSN journal
0720048X
Volume
18
Year of publication
1994
Supplement
1
Pages
190000021 - 190000031
Database
ISI
SICI code
0720-048X(1994)18:<190000021:TSAOIA>2.0.ZU;2-V
Abstract
The toxicology of pharmaceutical formulations of iomeprol, a new nonio nic iodinated radiographic contrast agent, was studied in rodents (mic e, rats and guinea-pigs) and non-rodents (rabbits and dogs). When inje cted intravascularly the acute toxicity of iomeprol, both in terms of median lethal dose and symptoms, was comparable to that of analogous t riiodinated nonionic contrast media (CM). Intravenous daily dosing for 4 weeks showed that iomeprol was well tolerated at doses as high as t he maximum dose anticipated for clinical use. Moreover, the compound d id not possess reproductive, developmental, or genetic toxicity. Tissu e tolerability was completely superimposable on those of reference CM such as iopamidol and iohexol. Finally, no antigenic potential was det ected either in mice or guinea-pigs. These favourable toxicological ch aracteristics bode well for iomeprol as an intravascular radiographic contrast agent.