ASSESSMENT OF THE SIDE-EFFECTS OF IOMEPROL

Adverse reactions were investigated in a group of 1918 patients enroll ed in a study for the clinical assessment of iomeprol. The incidence o f adverse reactions in the group was 5.3%. Dermatological symptoms wer e the principal adverse reactions. No previously unreported side-effec ts from iodinated contrast media were detected. Most adverse reactions were of slight or moderate intensity and most appeared within 3 h of the injection. The examinations which elicited a comparatively high fr equency of adverse reactions were cerebral angiography, abdominal angi ography, peripheral angiography, intravenous urography and thoracic an giography. No significant sex differences were noted with respect to t he occurrence of adverse reactions, but such effects were more frequen t among younger patients, among patients with allergic conditions and among patients who had previously received iodinated contrast media. A s regards the manner of injection of iomeprol, there were no definite trends in terms of the iodine concentration used or the quantity of co ntrast medium injected, but the incidence of adverse reactions was com paratively high for intravenous as compared with intra-arterial inject ion.