PROSTAGLANDIN-E2 PARATHYROID HORMONE-INDUCED SUPPRESSION OF ALKALINE-PHOSPHATASE ACTIVITY IS MEDIATED BY PROTEIN-KINASE-C

Authors
MIYA T TAGAWA M KATO N TAKAHASHI K SATO K FUJIMURA S
Citation
T. Miya et al., PROSTAGLANDIN-E2 PARATHYROID HORMONE-INDUCED SUPPRESSION OF ALKALINE-PHOSPHATASE ACTIVITY IS MEDIATED BY PROTEIN-KINASE-C, International Journal of Biochemistry, 26(5), 1994, pp. 639-643
Citations number
19
Categorie Soggetti
Biology
Journal title
International Journal of Biochemistry → ACNP
ISSN journal
0020711X
Volume
26
Issue
5
Year of publication
1994
Pages
639 - 643
Database
ISI
SICI code
0020-711X(1994)26:5<639:PPHSOA>2.0.ZU;2-U
Abstract
1. Bone resorptive factors, prostaglandin E2 and parathyroid hormone a re shown to suppress alkaline phosphatase activity in a rat osteoblast ic cell line. 2. Phorbol myristate acetate, but not dibutyryl cAMP or calcium ionophore can suppress alkaline phosphatase activity. 3. The p rotein kinase C inhibitors (H89, staurosporine) are able to block the suppression of alkaline phosphatase activity induced by prostaglandin E2 and parathyroid hormone. 4. These data suggest that protein kinase C is involved in the inhibition of alkaline phosphatase activity induc ed by prostaglandin E2 and parathyroid hormone.