Harlequin fetus is a rare clinical entity, and survival of affected in
fants beyond the first year of life is uncommon. Management involves i
ntensive care of the skin and eyes, close monitoring of fluid and elec
trolyte status, constant support and counselling of parents, and surve
illance against infection and side-effects of medication. A well-coord
inated multidisciplinary approach can prolong survival beyond the neon
atal period. We report our experiences in the management and follow-up
of two successive harlequin siblings.