AN ALGORITHM TO GENERATE LOW-RESOLUTION PROTEIN TERTIARY STRUCTURES FROM KNOWLEDGE OF SECONDARY STRUCTURE

Authors
MONGE A FRIESNER RA HONIG B
Citation
A. Monge et al., AN ALGORITHM TO GENERATE LOW-RESOLUTION PROTEIN TERTIARY STRUCTURES FROM KNOWLEDGE OF SECONDARY STRUCTURE, Proceedings of the National Academy of Sciences of the United Statesof America, 91(11), 1994, pp. 5027-5029
Citations number
24
Categorie Soggetti
Multidisciplinary Sciences
Journal title
Proceedings of the National Academy of Sciences of the United Statesof America → ACNP
ISSN journal
00278424
Volume
91
Issue
11
Year of publication
1994
Pages
5027 - 5029
Database
ISI
SICI code
0027-8424(1994)91:11<5027:AATGLP>2.0.ZU;2-D
Abstract
An algorithm is described to assemble the three-dimensional fold of a protein starting from its secondary structure. A reduced representatio n of the polypeptide chain is used together with a crude potential bas ed on pair hydrophobicities. The method is shown to be successful in l ocating the native topology for two 4-alpha-helix bundles, myohemeryth rin and cytochrome b-562.