MOLECULAR AND FUNCTIONAL-ANALYSIS OF A LYMPHOCYTE CHEMOATTRACTANT FACTOR - ASSOCIATION OF BIOLOGIC FUNCTION WITH CD4 EXPRESSION

Lymphocyte chemoattractant factor (LCF) is a lymphocyte cell product t hat stimulates a migratory response in CD4(+) lymphocytes, monocytes, and eosinophils. In concert with its chemoattractant activity, LCF ind uces human T-lymphocyte expression of interleukin 2 receptor. Here we describe the molecular cloning of cDNA encoding human LCF. It is a nov el interleukin with no significant homology to any previously describe d cytokine families. There is an absolute requirement for both autoagg regation of LCF monomers and for membrane-expressed CD4 molecules for LCF-induced migration in lymphocytes.