TEMAZEPAM 7.5 MG - EFFECTS ON SLEEP IN ELDERLY INSOMNIACS

Temazepam, 7.5 mg was evaluated in the sleep laboratory in 8 elderly i nsomniacs, using a 14-night protocol (4 placebo-baseline nights, 7 dru g nights, and 3 placebo-withdrawal nights). With short-term use temaze pam was found to be effective, producing a significant improvement in total wake time from baseline (100 vs. 145 min). With continued drug a dministration, total wake time remained below baseline but not signifi cantly so (125 vs. 145 min). During drug administration, there were no major CNS and behavioral adverse effects reported such as daytime sed ation, memory impairment or hyperexcitability (daytime anxiety). Follo wing drug withdrawal, there was no significant increase in wakefulness , i.e., no rebound insomnia (150 vs. 145 min). In summary, temazepam, 7.5 mg is effective in elderly subjects with short-term use and has a minimum of adverse effects. Use of hypnotic drugs is an adjunctive the rapy which should be for a short-term period with subsequent short-ter m intermittent use as needed. Because of its low propensity for produc ing rebound insomnia, temazepam can be effectively used in this manner .