DESIGN AND EVALUATION OF A ROTATING BASKET-PADDLE DISSOLUTION APPARATUS

The rotating basket-paddle dissolution apparatus is a combination of t he USP/NF rotating basket and rotating paddle. A comparative dissoluti on study was performed utilizing this new apparatus and the two USP/NF apparatus at various stirring speeds using non-disintegrating oxalic acid tablets and disintegrating aspirin tablets. The amount of drug re leased using the new apparatus was significantly higher than the rotat ing basket but significantly lower than the rotating paddle at each of the stirring speeds studied. The results obtained using this new appa ratus were highly reproducible compared to the USP/NF apparatus.