Diabetic muscle infarction (DMI) is a rare complication of diabetes me
llitus occurring in patients with poorly controlled insulin-dependent
diabetes. In previous reports, the diagnosis of this condition was bas
ed on the pathologic studies, although MRI examinations were performed
in a few patients as part of the diagnostic work-up. In this report,
we describe two additional cases of DMI where the diagnosis was based
on the MRI findings in conjunction with the clinical picture and labor
atory studies. The patients usually present with thigh or calf pain an
d swelling, are afebrile, and have normal white blood cell count. MRI
examination typically shows diffuse swelling and increased signal inte
nsity on T2-weighted images in the affected muscles, with no focal flu
id collections. In the proper clinical setting, these findings are dia
gnostic of DMI and patients should be spared unnecessary invasive diag
nostic examinations such as lower extremity venograms and biopsies.