Sexual problems are often reported to clinicians by women in the midli
fe years. Yet few of the epidemiological studies of women in midlife h
ave investigated the relationship of the menopause to sexual functioni
ng. This paper reports the results of a cross-sectional telephone surv
ey of 2001 randomly selected Australian-born women aged between 45 and
55 years. The major outcome variables were questions relating to chan
ges in sexual interest over the prior 12 months, reasons for any chang
es, occurrence of sexual intercourse, and of unusual pain on intercour
se. Logistic regression was used to identify explanatory variables for
change in sexual interest. The majority of women (62%) reported no ch
ange in sexual interest, although 31% reported a decrease. Decline in
sexual interest was significantly and adversely associated with natura
l menopause (p < 0.01) rather than age, decreased well-being (p < 0. 0
01), decreasing employment (p < 0.01) and symptomatology (vasomotor p
< 0.05, cardiopulmonary p < 0.001 and skeletal p < 0.01). Eleven to tw
elve years of education was associated with a lowered risk of decrease
d sexual functioning (p < 0.01). Heterogeneous results were reported b
y users of hormone replacement therapies. Longitudinal studies of larg
e and representative samples are needed to determine the etiology of a
dverse sexual changes with the menopause and the role of hormone repla
cement therapies.