EFFECT OF IRON ON THE ABSORPTION AND DISTRIBUTION OF CLODRONATE AFTERORAL-ADMINISTRATION IN RATS

The effect of iron on the absorption and distribution of disodium clod ronate in rats after oral administration was studied. Disodium clodron ate (300 mg/25 muCi/kg) was given both alone and with an equivalent am ount of ferrous sulphate. The radioactivity in plasma and various tiss ue was measured. Concentration of clodronate in plasma was also determ ined with the GC-mass-selective detection method and the values compar ed with those measured with the isotope method. After administration, clodronate was rapidly cleared from plasma. Most of the dose was taken up by bone and only small amounts were found in non-calcified tissues . Concurrent ingestion of iron caused a marked decrease in the absorpt ion of clodronate.