Staphylococcus aureus has long been known as one of the most virulent
microbes, with capabilities that make it threatening in both nosocomia
l and community-acquired infections. It remains the most frequent caus
e of skin-structure and traumatic infections in the community.(1) S. a
ureus infections in the maxillofacial region are likely to be associat
ed with a known portal of entry, but this is not always the case.(2) O
nce invasion occurs, the organism may produce virulent enzymes includi
ng coagulase, hyaluronidase, proteases, DNA-ase, hemolysins, and lysoz
yme as well as exotoxins.(3) Markel et als point out that cellulitis a
ssociated with coagulase-positive staphylococci will often resolve wit
hout abscess formation. Hence, there is often no site from which to ob
tain specimens, making this infection a diagnostic and therapeutic cha
llenge. This report describes an infection in which the etiologic orga
nism was identified as S. aureus. The source of the infection, however
remained unclear. ,