RECOVERY AFTER PROPOFOL INFUSION ANESTHESIA IN CHILDREN - COMPARISON WITH PROPOFOL, THIOPENTONE OR HALOTHANE INDUCTION FOLLOWED BY HALOTHANE MAINTENANCE

We have compared the recovery profiles of 163 healthy Chinese children after general anaesthesia for minor surgical procedures. Patients wer e allocated randomly to receive one of four anaesthetic techniques. pr opofol infusion for induction and maintenance using a pharmacokinetic model-controlled syringe pump set initially at a target concentration of 8 mu g ml(-1) and then adjusted according to clinical requirements; propofol 2.5-3.5 mg kg(-1), thiopentone 4-5 mg kg(-1) or 2-3% halotha ne for of anaesthesia followed by 1-2% for maintenance of anaesthesia. All patients breathed a mixture of 70% nitrous oxide in oxygen throug h a laryngeal mask airway and received an appropriate regional anaesth etic block. Recovery was assessed using the time to achieve full Stewa rd score, open eyes on command, orientation and the time required to c omplete a simple puzzle. Recovery was slowest with the propofol infusi on (mean 39.8 (SD 12.9) min when eyes opened on command). The recovery times were significantly shorter with the three other techniques (pro pofol bolus 21.9 (9.9) min, thiopentone 23.4 (11.3) min, halothane 20. 1 (8.9) min), and the choice among these three methods had no signific ant influence on the recovery profile.