SEQUENTIAL CYTOGENETIC STUDY OF PATIENTS AFTER BONE-MARROW TRANSPLANTATION

Thirty-one patients (19 males and 12 females; mean age 23.9 years, ran ge 4-41 years) were treated with bone marrow transplantation (BMT) aft er intensive chemoradiotherapy. Their diagnoses were as follows: chron ic myeloid leukemia (CML) in 13, acute myeloid leukemia (AML) in seven , acute lymphocytic leukemia (ALL) in six, myelodysplastic syndrome (M DS) in two, aplastic anemia (AA) in two, and Fanconi anemia (FA) in on e. Allogeneic BMT was performed in 28 cases (17 donors were of like se x, 11 were of unlike sex), one patient received syngenic transplant, a nd one received transplant of cells obtained from an unrelated donor t hrough a computerized international registry in London. Autologous BMT was performed in three patients. BM cells were analyzed cytogenetical ly at diagnosis, before and serially after BMT (three to nine times). Follow-up ranged from 2 to 55.5 months. Cytogenetic examination was a very useful method for monitoring posttransplantation course in patien ts with CML or in those who received BM cells of unlike sex. Results o f concomitant cytogenetic examinations are reported in detail.