TRANSLOCATION (8,17)(P21,Q21), A POSSIBLE VARIANT OF T(15,17), IN ACUTE PROMYELOCYTIC LEUKEMIA

Authors
MIURA I NISHINARI T HASHIMOTO K NIMURA T MIURA S MIURA AB
Citation
I. Miura et al., TRANSLOCATION (8,17)(P21,Q21), A POSSIBLE VARIANT OF T(15,17), IN ACUTE PROMYELOCYTIC LEUKEMIA, Cancer genetics and cytogenetics, 72(1), 1994, pp. 75-77
Citations number
13
Categorie Soggetti
Oncology,"Genetics & Heredity
Journal title
Cancer genetics and cytogenetics → ACNP
ISSN journal
01654608
Volume
72
Issue
1
Year of publication
1994
Pages
75 - 77
Database
ISI
SICI code
0165-4608(1994)72:1<75:T(APVO>2.0.ZU;2-R
Abstract
We report a 64-year old man with typical features of acute promyelocyt ic leukemia (APL) [M3, French-American-British (FAB) classification] i n whom a variant, t(8;17)(q21;q21), was detected. This is the second c ase of the same variant translocation to be reported. The breakpoint o n 17q was similar to those described in cases with a standard transloc ation 15;17. Consequently, this chromosome break or rearrangement at b and 17q21, rather than the recipient site of translocation of the dele ted material, appears to be of crucial importance in the genesis of AP L.