The membrane attack complex of complement is formed by the molecular f
usion of the five terminal complement proteins, C5, C6, C7, C8, and C9
. While the assembly process on a target membrane and its modulation b
y restriction factors present on host cells is now quite well understo
od the molecular details of the architecture of the complex still need
much further clarification. This is especially true for the interacti
on of the last acting protein C9, which provides the cytotoxic action
of the complex, with the precursor C5b-8 complex. Because of this lack
of structural details the molecular mechanisms that lead to complemen
t-mediated cell death remain cryptic, however, it is hoped that recent
advances in controlling the assembly process and in site-specific mod
ification of the terminal complement proteins by recombinant DNA techn
iques should change this predicament quickly.