SOME DESMOID TUMORS ARE CHARACTERIZED BY TRISOMY-8

Ten desmoid tumors were examined by chromosome banding analysis and by in situ hybridization on short-term cultures and frozen sections. Tri somy 8 was detected in four out of ten tumors, of which only one had s hown trisomy 8 by karyotype analysis. Since trisomy 8 has been reporte d in superficial fibromatoses, which are clinically distinct but histo logically similar to desmoid tumors, the occurrence of trisomy 8 in bo th may be a further indication of a close relationship. (C) 1994 Wiley -Liss, Inc.