NO TP53 MUTATIONS IN NEUROBLASTOMAS DETECTED BY PCR-SSCP ANALYSIS

Authors
CASTRESANA JS BELLO ML REY JA NEBREDA P QUEIZAN A GARCIAMIGUEL P PESTANA A
Citation
Js. Castresana et al., NO TP53 MUTATIONS IN NEUROBLASTOMAS DETECTED BY PCR-SSCP ANALYSIS, Genes, chromosomes & cancer, 10(2), 1994, pp. 136-138
Citations number
20
Categorie Soggetti
Oncology,"Genetics & Heredity
Journal title
Genes, chromosomes & cancer → ACNP
ISSN journal
10452257
Volume
10
Issue
2
Year of publication
1994
Pages
136 - 138
Database
ISI
SICI code
1045-2257(1994)10:2<136:NTMIND>2.0.ZU;2-U
Abstract
We have analysed 29 neuroblastomas for TP53 mutations in exons 5 to 8 by means of the polymerase chain reaction in combination with the sing le-strand conformation polymorphism technique. We could not detect any mutation. These results indicate that, in contrast to the majority of tumors so far studied, TP53 mutations do not seem to be important for the development of neuroblastomas. (C) 1994 Wiley-Liss, Inc.