P. Ghosh et al., ALTERATIONS IN NF-KAPPA-B REL FAMILY PROTEINS IN SPLENIC T-CELLS FROMTUMOR-BEARING MICE AND REVERSAL FOLLOWING THERAPY/, Cancer research, 54(11), 1994, pp. 2969-2972
It has recently been shown that T-cell signal transduction molecules a
re altered in tumor-bearing mice. We have examined the expression of N
F kappa B/Rel family proteins in T-cells from mice bearing Renca, a mu
rine renal carcinoma. T-cells from Renca-bearing mice expressed undete
ctable levels of nuclear c-Rel, NF kappa B p65, and p50; however two s
horter forms of p50 (p48 and p46), truncated at the NH2-terminus, were
present exclusively in the nucleus and were able to bind DNA. These T
-cells have reduced expression of gamma-interferon mRNA. In mice succe
ssfully treated with flavone 8-acetic acid and recombinant human inter
leukin 2, the T-cells expressed normal levels of all three nuclear NF
kappa B/Rel proteins. These results suggest that alterations in transc
ription factors may accompany changes in signal transduction molecules
in T-cells from tumor-bearing animals; however, the changes are rever
sed with successful biological therapy.