AMINOPYRAZINYL DERIVATIVES - SYNTHESIS AND EVALUATION OF ANTIINFLAMMATORY AND RELATED ACTIVITIES

Some amides, 1-substituted methylenediamines and 2-substituted thiazol idin-4-ones, all containing the aminopyrazinyl moiety, were synthesize d and tested in the experimental models of acute and chronic inflammat ions and as potential analgesic agents. The first series of compounds are inactive, whereas the N,N'-di-(2-pyrazinyl)-methylene-diamines and the 3-(2'-pyrazinyl)-thiazolidinones 6, 7, 11, 12 and even more 16 an d 17 were found to be endowed with antiinflammatory and analgesic prop erties and low acute toxicity, the two latter being the most interesti ng.