AN AUTOPSY CASE OF PSP WITH ASTROCYTIC INCLUSIONS

Argyrophilic glial cytoplasmic inclusions were observed in astrocytes (Astrocytic Inclusions) in a case of progressive supranuclear palsy (P SP). The inclusions were predominantly distributed in the lenticular n ucleus and midbrain, but not in the cerebral cortex, white matter nor in the thalamus. When examined by double staining with Gallyas silver and GFAP, they resembled the neurofibrillary tangles (NFT) and were ta u positive. The distribution of these inclusions was not related to th at of NFT. These inclusions indicate that astrocytes were involved in the same pathological changes as NFT. Argyrophilic inclusions were als o observed in oligodendroglias on Gallyas silver staining. They appear ed coiled and located mainly in the cerebral and cerebellar white matt er.