FOLLICULAR TOXIC PUSTULODERMA ASSOCIATED WITH ALLOPURINOL

Allopurinol is widely prescribed for primary and secondary hyperuricae mia, and cutaneous adverse reactions are seen in 0.8-2.1% of recipient s.1,2 The majority of these are mild and include pruritus, diffuse or maculo-papular erythema, urticaria and ichthyosis.3 More severe reacti ons are well recognized and include exfoliative dermatitis, toxic epid ermal necrolysis and a generalized hypersensitivity syndrome.3-5 The l atter typically comprises fever, rash, hepatic and renal dysfunction a nd eosinophil leucocytosis.5 The occurrence of toxic pustuloderma due to allopurinol, confirmed by re-challenge, is reported.