HYPERTENSIVE REACTION DURING COMBINED THE RAPY OF MOCLOBEMIDE, TRIMIPRAMINE WITH OMEPRAZOLE

Newer antidepressants like the selective serotonin-reuptake-inhibitors (SSRI) and the reversible inhibitors of amine oxidase-A moclobemide ( RIMA) are prescribed as well from internists and general practitioners because of their lack of anticholinergic side effects. In this connec tion it must be paid attention especially to the interactions with int ernal co-medication. The presented case report describes the significa nce of drug-monitoring with a depressive comorbid patient resistant to treatment who developed during a combined therapy of moclobemide with trimipramine, neuroleptics co-medicated with omeprazol an agitated st atus with neurological and cardiovascular symptoms which we consider t o be a beginning serotonin syndrome. Beside the necessary drug-monitor ing it is advisable to classify the pharmacogenetic status of risk pat ients.