REPAIR OF FASCIA WITH POLYGLYCOLIC - ACID MESH CULTURED WITH FIBROBLASTS - EXPERIMENTAL-STUDY

In the present study polyglycolic acid (PGA) mesh was used for repair of fascial defects experimentally made in rats, In the experimental gr oup fibroblasts were cultured on the mesh before implantation and in t he control group the mesh alone was used, Rats were sacrificed 7, 14, 28 and 60 days after the implantation of the mesh, Tissues were examin ed microscopically and for phydroxyproline content, Microscopically go od incorporation of the mesh was noted in both the control and experim ental groups. However, it seems that in the experimental group earlier dissolution of the mesh occurred. The hydroxyproline content was high er in the experimental group after 7 (statistically not significant) a nd 14 days (p < 0.05) and in the control group after 28 (p ( 0.025) an d 60 days (p < 0.05), These results suggest that the use of PGA mesh w ith cultured fibroblasts might have a beneficial effect on wound heali ng.