THE YEAST YKL741 GENE SITUATED ON THE LEFT ARM OF CHROMOSOME-XI CODESFOR A HOMOLOG OF THE HUMAN ALD PROTEIN

The yeast gene YKL741 is situated on the left arm of chromosome XI, 12 kb closer to the centromere with respect to the previously localized PAS1 gene. The new yeast gene codes for a homologue of the human ALD p rotein (ALD: adrenoleukodystrophy). The similarity between the YKL741 protein and the ALD protein is very high in the C-terminal half, which contains an ATP-binding cassette characteristic of the ABC family of transporters. Additionally the YKL741 protein shows some similarity to the ALD protein in the N-terminal half in three putative transmembran e spanning domains. The sequence has been deposited in the EMBL data l ibrary under Accession Number X76133 SC YKL.