AN EXPERIMENTAL-STUDY AN EFFECTS OF OCCLUSION OF THE CYSTIC DUCT IN MICE WITH OR WITHOUT EMPTYING OF THE GALLBLADDER

Citation
E. Trondsen et al., AN EXPERIMENTAL-STUDY AN EFFECTS OF OCCLUSION OF THE CYSTIC DUCT IN MICE WITH OR WITHOUT EMPTYING OF THE GALLBLADDER, European surgical research, 29(2), 1997, pp. 150-158
Citations number
10
Categorie Soggetti
Surgery
Journal title
ISSN journal
0014312X
Volume
29
Issue
2
Year of publication
1997
Pages
150 - 158
Database
ISI
SICI code
0014-312X(1997)29:2<150:AEAEOO>2.0.ZU;2-8
Abstract
To study consequences of cystic duct occlusion, 121 NMRI mice were ope rated: 40 had cystic duct ligature (L group), 41 had cystic duct ligat ure and evacuation of bile from the gallbladder (LE group), and 40 wer e sham-operated (S group), Ten mice from each group were sacrificed at 1 week, 1, 3 and 6 months, respectively. All but 2 mice showed signs of wellbeing during the observation time, and weight gain was the same in the three groups. Distended gallbladder occurred in 14 animals, 7 each in the L and the LE group, more frequent after 3 and 6 months. In the remainder mice the gallbladders were smaller than at the time of operation (p < 0.0001). Fibrosis and adhesions around the gallbladder were frequent in the L and the LE groups, and more pronounced in the l atter (p = 0.0001). At microscopy there were signs of inflammation in the gallbladder wall in 16 cases in the L group, 28 In the LE group an d 2 in the S group, and the degree of inflammation was more pronounced in the LE group than in the L group (p = 0.002). Eleven mice in the L E group had empyema, and slight intralumininal inflammation was more f requent in the LE group than in the L group (p < 0.0001). In conclusio n, despite a high incidence of microscopic inflammation the Study gave no indication that occlusion of the cystic duct did serious harm to t he mice in this series.