CD2-FREE CA2+ CONCENTRATION IN CAT ADRENAL CHROMAFFIN CELLS( AND CO2+MICROMOLAR CONCENTRATIONS STIMULATE CATECHOLAMINE SECRETION BY INCREASING THE CYTOSOLIC)

Authors
YAMAGAMI K NISHIMURA S SORIMACHI M
Citation
K. Yamagami et al., CD2-FREE CA2+ CONCENTRATION IN CAT ADRENAL CHROMAFFIN CELLS( AND CO2+MICROMOLAR CONCENTRATIONS STIMULATE CATECHOLAMINE SECRETION BY INCREASING THE CYTOSOLIC), Brain research, 646(2), 1994, pp. 295-298
Citations number
16
Categorie Soggetti
Neurosciences
Journal title
Brain research → ACNP
ISSN journal
00068993
Volume
646
Issue
2
Year of publication
1994
Pages
295 - 298
Database
ISI
SICI code
0006-8993(1994)646:2<295:CCCICA>2.0.ZU;2-8
Abstract
Cd2+ and Co2+ at micromolar concentrations increased the cytosolic fre e Ca2+ concentration, which was measured by fura-2 microfluorometry, i n cat adrenal chromaffin cells. Simultaneously, these divalent cations stimulated catecholamine secretion from the perfused adrenal. The pre sent findings suggest that these cations increase the Ca2+ influx by d epolarizing the cell membrane and consequently stimulate catecholamine secretion.