BETA-AMYLOID INCREASES CHOLINE CONDUCTANCE OF PC12 CELLS - POSSIBLE MECHANISM OF TOXICITY IN ALZHEIMERS-DISEASE

Authors
GALDZICKI Z FUKUYAMA R WADHWANI KC RAPOPORT SI EHRENSTEIN G
Citation
Z. Galdzicki et al., BETA-AMYLOID INCREASES CHOLINE CONDUCTANCE OF PC12 CELLS - POSSIBLE MECHANISM OF TOXICITY IN ALZHEIMERS-DISEASE, Brain research, 646(2), 1994, pp. 332-336
Citations number
22
Categorie Soggetti
Neurosciences
Journal title
Brain research → ACNP
ISSN journal
00068993
Volume
646
Issue
2
Year of publication
1994
Pages
332 - 336
Database
ISI
SICI code
0006-8993(1994)646:2<332:BICCOP>2.0.ZU;2-9
Abstract
When beta-amyloid-(1-40) is added to PC12 cells, there is an increase in choline conductance that is proportional to the beta-amyloid concen tration. If a similar effect occurs in cholinergic brain cells of Alzh eimer's disease patients, the intracellular choline concentration woul d be reduced, leading to a decrease in the production of acetylcholine . This could explain the reduced level of acetylcholine that has been found in post-mortem brain tissue of Alzheimer's disease patients.