The radiological diagnosis of Paget's disease of bone is usually strai
ghtforward because most cases conform to well-established classic desc
riptions. Diagnosis becomes more difficult, however, when radiological
appearances are not typical or other disease processes mask or alter
the behavior of Paget's disease. Examples are presented to illustrate
four categories of unusual radiological presentation of Paget's diseas
e: (1) unusual disease progression, (2) massive post-immobilization ly
sis, (3) metastatic spread to pagetic bone, and (4) vertebral end-plat
e destruction that mimics infection.