INHIBITION OF ANGIOGENESIS AS A STRATEGY FOR TUMOR-GROWTH CONTROL

Angiogenesis is a complex sequence of events leading to the formation of new capillaries. Although essential to maturation and wound healing , most angiogenesis in the adult is associated with pathological event s, such as the development of solid tumors. One approach to the inhibi tion of angiogenesis is the antagonism of basic fibroblast growth fact or, a major angiogenic protein. Evidence is reviewed to suggest that i nhibiting angiogenesis results in the suppression of tumor growth.