NEUROTOXICITY OF IMMUNOTOXINS

Authors
ILERCIL O LASKE DW WALBRIDGE S MUASZKO K OLDFIELD EH YOULE RJ
Citation
O. Ilercil et al., NEUROTOXICITY OF IMMUNOTOXINS, Molecular and chemical neuropathology, 21(2-3), 1994, pp. 379-386
Citations number
22
Categorie Soggetti
Pathology,Neurosciences
Journal title
Molecular and chemical neuropathology → ACNP
ISSN journal
10447393
Volume
21
Issue
2-3
Year of publication
1994
Pages
379 - 386
Database
ISI
SICI code
1044-7393(1994)21:2-3<379:NOI>2.0.ZU;2-F
Abstract
Immunotoxins are being tested for the therapy of systemic cancer and b rain tumors. Neurotoxicity has been dose limiting for several of these antibody conjugates given systemically. We review the animal and clin ical data related to the neurotoxicity of immunotoxins in attempt to u nderstand the molecular basis for the unexpected neural involvement an d to prevent or minimize this toxicity in future clinical trials.