P. Bendtsen et al., TREATMENT PERSPECTIVES IN RHEUMATOID-ARTHRITIS - A DESCRIPTIVE STUDY IN A SWEDISH HEALTH-CARE DISTRICT, PharmacoEconomics, 5(5), 1994, pp. 399-407
This study analyses patterns of treatment offered to individuals with
a clinical diagnosis of rheumatoid arthritis (RA). A cross-sectional i
nvestigation was carried out in 321 patients (aged >16 years) fulfilli
ng the 1958 American Rheumatism Association (ARA) criteria for RA. Med
ical records were scrutinised retrospectively for information about me
dical, surgical and other treatments during a 5-year period (1982 to 1
986). All patients had received medical treatment, but a large number
had discontinued drug therapy because of adverse effects or lack of ef
ficacy. 45.9% of the individuals were receiving 1 drug at the time of
the survey, 33.8% were on 2 drugs, 11.7% were on 3 or 4 drugs, and 8.6
% were not receiving any medication, Nearly 50% of the patients had ha
d various kinds of surgical procedures performed. The clinical manifes
tation of the disease, as measured by the number of ARA criteria fulfi
lled, showed a linear correlation to nearly all medical and surgical t
reatments. A primary healthcare physician was the basic contact person
for 90% of the patients, but in addition 70% of the participants had
been examined at sometime by a rheumatological specialist. The study c
onfirms our expectations that patients with RA receive numerous pharma
ceutical and other treatments. Even patients with mild and/or early di
sease (probable RA) had received a considerable amount of treatment. Q
ualified specialised care was also provided despite the distance to a
university referral centre. Increased compliance by patients receiving
drug therapy for RA might have pharmacoeconomic benefits through a lo
wer incidence of discontinuation of treatment due to lack of effect.