INHIBITION OF HUMAN IMMUNODEFICIENCY VIRUS-1 PROTEASE BY A C(2)-SYMMETRICAL PHOSPHINIC ACID AMIDE

Authors
PEYMAN A WAGNER K BUDT KH SPANIG J RUPPERT D MEICHSNER C PAESSENS A
Citation
A. Peyman et al., INHIBITION OF HUMAN IMMUNODEFICIENCY VIRUS-1 PROTEASE BY A C(2)-SYMMETRICAL PHOSPHINIC ACID AMIDE, Bioorganic & medicinal chemistry letters, 4(10), 1994, pp. 1191-1194
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
10
Year of publication
1994
Pages
1191 - 1194
Database
ISI
SICI code
0960-894X(1994)4:10<1191:IOHIVP>2.0.ZU;2-Y
Abstract
The inhibition of HIV protease with C2-symmetric phosphinic acid based inhibitors is independent of the dissociation grade of the phosphinic acid. The corresponding amides are not only good inhibitors of HIV pr otease but also inhibit HIV replication in vitro because of their incr eased lipophilicity.