MIXED OLIGONUCLEOTIDE ANALOGS WITH AN ACYCLIC CARBOHYDRATE MOIETY ANDA N-CYANOGUANIDINE FUNCTIONALITY

Authors
PANNECOUQUE C SCHEPERS G ROZENSKI J VANAERSCHOT A CLAES P HERDEWIJN P
Citation
C. Pannecouque et al., MIXED OLIGONUCLEOTIDE ANALOGS WITH AN ACYCLIC CARBOHYDRATE MOIETY ANDA N-CYANOGUANIDINE FUNCTIONALITY, Bioorganic & medicinal chemistry letters, 4(10), 1994, pp. 1203-1206
Citations number
12
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
10
Year of publication
1994
Pages
1203 - 1206
Database
ISI
SICI code
0960-894X(1994)4:10<1203:MOAWAA>2.0.ZU;2-B
Abstract
Mixed oligonucleotide analogues having a backbone structure with a N-c yanoguanidine functionality and an acyclic sugar moiety were synthesiz ed This combination, however, has a detrimental effect on duplex stabi lity of DNA-DNA hybrids.