SYNTHESIS AND BIOLOGICAL-ACTIVITY OF INTERCALATOR SUBSTITUTED BILE STEROIDS

Authors
BROWN CL HARDING MM KALMAN JR MARJO CE RAINONE S WEBSTER LK
Citation
Cl. Brown et al., SYNTHESIS AND BIOLOGICAL-ACTIVITY OF INTERCALATOR SUBSTITUTED BILE STEROIDS, Bioorganic & medicinal chemistry letters, 4(10), 1994, pp. 1253-1256
Citations number
11
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
10
Year of publication
1994
Pages
1253 - 1256
Database
ISI
SICI code
0960-894X(1994)4:10<1253:SABOIS>2.0.ZU;2-U
Abstract
Cholic acid has been functionalised at the 3 and 24 positions with qui noline and quinoxaline chromophores. The 24-quinoline monoester shows significant activity against L1210 mouse leukaemia cells compared to t he 3,24-disubstituted quinoline and quinoxaline esters.