Rk. Pandey et al., SYNTHESES OF NEW BACTERIOCHLORINS AND THEIR ANTITUMOR-ACTIVITY, Bioorganic & medicinal chemistry letters, 4(10), 1994, pp. 1263-1267
Purpurin-18 methyl ester la was converted into a series of new bacteri
ochlorins 2b, 2c, 2f and 4b. These stable bacteriochlorins have strong
long wavelength absorptions in the range of 760 to 816 nm, and were t
ested for in vivo photosensitizing activity using the standard screeni
ng system of DBA/2 mice bearing transplanted SMT/F tumors. In prelimin
ary screening, among the photosensitizers tested so far, bacteriochlor
ins 2f and 4b have shown promising anti-tumor activity.