Purpose: While intrafamilial morphologic heterogeneity of autosomal do
minant congenital cataracts has been well established, interocular var
iation in individual patients of described pedigrees is small. The aut
hors describe a seven-generation family with 48 of 138 individuals kno
wn to be affected with autosomal dominant congenital cataracts of the
pulverulent type. Affected patients exhibit a seemingly random express
ion of either unilateral or bilateral lens opacities. Methods: Ophthal
mic and medical histories were obtained, complete ophthalmologic exami
nations were performed, blood samples were drawn, and transformed lymp
hoblastoid lines were established on 53 patients. Eighty-five members
of the family were unable to be examined. Results: Twenty-eight of the
53 individuals examined had congenital cataracts. Of these patients,
19 eyes (8 right eyes and 11 left eyes) were unilateral and 9 were bil
ateral. The clinically unaffected eye in patients with unilateral cata
racts showed no evidence of lenticular opacity under detailed slit-lam
p examination. Severity of the cataracts included a subtle unilateral
zonular cataract with 20/20 visual acuity, bilateral inner fetal nucle
ar pulverulent opacities with 20/16 visual acuity in both eyes, and de
nse unilateral and bilateral nuclear cataracts requiring early surgica
l removal. Incorporating the historic data on patients who were not ex
amined, we found 48 affected members (28 unilateral, 17 bilateral, 3 o
bligate carriers who were not examined). Conclusions: Hereditary catar
acts typically are symmetric in affected individuals. The authors desc
ribe a large pedigree with the apparently random expression of an auto
somal dominant gene as either unilateral or bilateral cataract. To the
ir knowledge, this is the first such family described in the literatur
e. Currently, work is under way to determine if the causative gene is
linked to previously defined cataract loci on chromosomes 1, 2, or 16.