NEUROLOGICAL COMPLICATIONS FROM FAT EMULSION THERAPY

Fat emulsion therapy is convenient for parenterally administering calo ries and essential fats. We report 2 children with neurological compli cations of fat emulsion therapy that arose before any systemic finding s. The complications included focal and generalized seizures, weakness , and altered mental status. Biopsy and autopsy findings included cere bral endothelial and intravascular lipid deposition. Early recognition of fat emulsion therapy complications is essential as the neurologica l complications are potentially reversible with alteration of the pare nteral diet.