BLOCKADE OF THALAMIC GABA(B) RECEPTORS DECREASES EEG SYNCHRONIZATION

Authors
JUHASZ G EMRI Z KEKESI KA SALFAY O CRUNELLI V
Citation
G. Juhasz et al., BLOCKADE OF THALAMIC GABA(B) RECEPTORS DECREASES EEG SYNCHRONIZATION, Neuroscience letters, 172(1-2), 1994, pp. 155-158
Citations number
17
Categorie Soggetti
Neurosciences
Journal title
Neuroscience letters → ACNP
ISSN journal
03043940
Volume
172
Issue
1-2
Year of publication
1994
Pages
155 - 158
Database
ISI
SICI code
0304-3940(1994)172:1-2<155:BOTGRD>2.0.ZU;2-8
Abstract
The gamma-aminobutyric acid (GABA)(B) receptor antagonists 2-OH-saclof en and CGP 35348 were injected in the thalamus of freely moving cats v ia a microdialysis probe while recording the sleep-waking cycle. The r esults obtained with the two antagonists were similar: wakefulness and the total sleep time were not affected by the blockade of GABA(B) rec eptors, but deep slow wave sleep and the mean power of slow waves (<10 Hz) were decreased, while light slow wave sleep was increased. These data suggest an involvement of thalamic GABA(B) receptors in the regul ation of EEG slow waves.