STRUCTURE-ACTIVITY-RELATIONSHIPS IN THIENODIAZEPINE AND BENZODIAZEPINE DERIVATIVES

Authors
CHIMIRRI A GITTO R GRASSO S ZAPPALA M DESARRO A DESARRO GB
Citation
A. Chimirri et al., STRUCTURE-ACTIVITY-RELATIONSHIPS IN THIENODIAZEPINE AND BENZODIAZEPINE DERIVATIVES, Il Farmaco, 49(3), 1994, pp. 193-196
Citations number
24
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Il Farmaco → ACNP
ISSN journal
0014827X
Volume
49
Issue
3
Year of publication
1994
Pages
193 - 196
Database
ISI
SICI code
0014-827X(1994)49:3<193:SITAB>2.0.ZU;2-5
Abstract
The structural and electronic characteristics as well as the anticonvu lsant properties and benzodiazepine receptor binding of thieno[3,4-b][ 1,4]diazepine and 1,5-benzodiazepine derivatives are compared and disc ussed. The data obtained suggest that the electronic rather than the s tructural properties appear mainly responsible for the variant degree of anticonvulsant activity exhibited by the tested compounds.