TRIFLUOROMETHYL-CONTAINING SULFANILAMIDES .1. SYNTHESIS AND IN-VITRO ANTIBACTERIAL ACTIVITY

In a wider research directed to improve pharmacological profiles of kn own antiinfective agents by introducing fluorine or trifluoromethyl gr oups, some sulfanilamides trifluoromethylsubstituted on N1 ring, were synthesized and examined for their in vitro activity against gram-posi tive and gram-negative bacteria. Two N1-trifluoromethylphenyl-sulfanil amides, 1 and 4, exhibited MIC values, against all tested bacteria, si milar or lower than those of the ''classical'' sulfanilamides, assayed in comparison. The new sulfanilamide 4 appears to be the more interes ting: in fact, the presence of p-aminobenzoic acid (PABA) in culture m edium did not influence its MIC values and no synergy was observed wit h trimethoprim, suggesting mechanism of action different from that of known sulfanilamides.