HYPERVOLEMIC HEMODILUTION WITH OR WITHOUT VENESECTION IN PERIPHERAL ARTERIAL OCCLUSIVE DISEASE STAGE-II

Patients with peripheral arterial occlusive disease (PAOD) and marked atherosclerosis often present concomitant diseases like coronary heart disease, cerebral circulatory disorders or arterial hypertension. Thu s, the extent of hypervolemia is limited in case of an infusion treatm ent without venesection. Therefore, it was tested whether a hypervolem ic hemodilution without venesection is superior to a dilution with ven esection in multimorbid patients suffering from PAOD stage II. The col loidal iso-molar solution used was Haes 200/0.5 6%. Both forms of hemo dilution were significantly superior compared to a control group well hydrated with cristalloid saline solution; all groups practised walkin g exercise twice a week over a period of one hour. However, hypervolem ic hemodilution without venesection was only slightly better than the dilution with venesection. The walking distance in the group without v enesection increased by 68.6 m (36.7%) in the group without venesectio n, by 59.0 (30.4%) in the group with venesection and by 33.6 m (20.1%) in the control group. The results show that the decision to perform a hyper-or isovolemic hemodilution should depend on the volume toleranc e of each patient.