THE EFFECT OF EXOGENOUS PHOSPHOCREATINE ON MAXIMAL WALKING DISTANCE, BLOOD RHEOLOGY, PLATELET-AGGREGATION, AND FIBRINOLYSIS IN PATIENTS WITH INTERMITTENT CLAUDICATION

Thirty-seven men with angiography or ultrasound confirmed peripheral a rterial occlusive disease were divided into two groups. Group 1 includ ed 24 patients treated with one daily infusion of 10 g of phosphocreat ine in 200 ml of solvent for 10 days. Group 2 included 13 patients who were given 0.9% NaCl in the same scheme. Groups were comparable in: d uration of intermittent claudication, maximal walking distance, Ketle index, cholesterol, triglycerides, frequency of ischemic heart disease , hypertension, diabetes, smoking. Patients were examined 4 times: bef ore starting, on second day, after treatment period, and 1 month after . Treadmill-test; ADP-, PAF-, 5-HT-induced platelet aggregation; D-dim er; PAI-1 activity; blood viscosity at high and low shear rate; hemato crit were performed. After treatment maximal walking distance signific antly increased in patients of Group 1. Mechanisms of this effects inc lude positive influence of phosphocreatine on platelet aggregation, bl ood rheology, coagulation and fibrinolytic systems.