SEQUENCING AND ANALYSIS OF A 20.5-KB DNA SEGMENT LOCATED ON THE LEFT ARM OF YEAST CHROMOSOME-XI

A 20.5 kb DNA fragment from the left arm of chromosome XI of Saccharom yces cerevisiae has been sequenced and analysed. Thirteen open reading frames (ORFs) for proteins longer than 100 amino acids were discovere d. Among them, two are the known genes MRP49 and TPK3; two others enco de proteins which show strong similarity with a yeast putative protein kinase and a yeast choline transport protein; one other shows weaker similarity with a yeast Ca2+/calmodulin-dependent protein kinase. More over, two putative proteins encoded by ORFs located in the sequenced f ragment are closely similar to non-yeast proteins: the Caenorhabditis elegans elongation factor 2 and a glutamic acid-rich protein of Plasmo dium falciparum. The sequence has been deposited in the EMBL data libr ary under Accession Number Z26878.