Md. Fernandeztome et Nb. Sterinspeziale, SHORT-TERM AND LONG-TERM TREATMENT WITH INDOMETHACIN CAUSES RENAL PHOSPHOLIPID ALTERATION - A POSSIBLE EXPLANATION FOR INDOMETHACIN NEPHROTOXICITY, Pharmacology, 48(6), 1994, pp. 341-348
Phospholipid content was studied in kidneys from rats treated with ind
ometacin. Short-term treatment was performed by using low(l and 5 mg/k
g/day) and high(10 and 50 mg/kg/day) doses of indometacin. Long-term t
reatment was achieved by using only low doses of indometacin. Short-te
rm treatment at low doses did not result in any change in the phosphol
ipid content. In rats administered higher concentrations, indometacin
caused a marked increase in all papillary phospholipid contents, but n
o effect was observed in the medulla, and an increase in sphingomyelin
and phosphatidylethanolamine was observed in the cortex. Long-term tr
eatment with administration of 1 mg/kg/day of indometacin led to an in
crease in all papillary phospholipids from the 2nd week of treatment.
Medullary phospholipids also increased, but no changes were observed i
n cortical phospholipids. These results show that indometacin causes p
hospholipid accumulation in rat kidney and that the papilla is the mos
t sensitive renal tissue.