VERAPAMIL IS NOT AN ANTIDEPRESSANT IN PATIENTS RESISTANT TO TRICYCLICANTIDEPRESSANTS

Authors
ADLERSBERG S TOREN P MESTER R REHAVI M SKOLNICK P WEIZMAN A
Citation
S. Adlersberg et al., VERAPAMIL IS NOT AN ANTIDEPRESSANT IN PATIENTS RESISTANT TO TRICYCLICANTIDEPRESSANTS, Clinical neuropharmacology, 17(3), 1994, pp. 294-297
Citations number
28
Categorie Soggetti
Pharmacology & Pharmacy",Neurosciences
Journal title
Clinical neuropharmacology → ACNP
ISSN journal
03625664
Volume
17
Issue
3
Year of publication
1994
Pages
294 - 297
Database
ISI
SICI code
0362-5664(1994)17:3<294:VINAAI>2.0.ZU;2-0
Abstract
The effects of a calcium channel blocker (verapamil, 160-320 mg/day fo r 4 weeks) were studied in seven unipolar major-depressed patients res istant to treatment with tricyclic antidepressants. This regimen of ve rapamil did not alter either the Hamilton rating scales for depression and anxiety or the Beck depression inventory score in these patients. Thus, verapamil appears devoid of antidepressant properties in patien ts resistant to tricyclic antidepressants.