D. Bunnag et al., HIGH-DOSE OF PRIMAQUINE IN PRIMAQUINE RESISTANT VIVAX MALARIA, Transactions of the Royal Society of Tropical Medicine and Hygiene, 88(2), 1994, pp. 218-219
Citations number
14
Categorie Soggetti
Public, Environmental & Occupation Heath","Tropical Medicine
The efficacy of low dose chloroquine, characteristic pattern of relaps
e and the relapse rate in vivax malaria after high dose primaquine wer
e investigated in 167 Thai patients. 87 patients were allocated at ran
dom to receive 300 mg, and 80 received 450 mg of chloroquine on the fi
rst day of admission. All patients in both groups showed a rapid respo
nse with comparable fever clearance times (27.3 vs. 26.1 h) and parasi
te clearance times (67.1 vs. 58.1 h). After recovery and clearance of
parasitaemia, the patients were allocated at random (double blind) to
receive 2 dosage regimens of primaquine, a daily dose of 15 mg or 22.5
mg for 14 d. Relapses in both groups occurred within 6 months; no pat
ient relapsed beyond that period. The relapse rate in the primaquine 1
5 mg group was significantly higher than that in the 22.5 mg group (17
.5% vs. 2.4%).