AMINOSIDINE OINTMENTS FOR THE TREATMENT OF EXPERIMENTAL CUTANEOUS LEISHMANIASIS

Authors
NEAL RA MURPHY AG OLLIARO P CROFT SL
Citation
Ra. Neal et al., AMINOSIDINE OINTMENTS FOR THE TREATMENT OF EXPERIMENTAL CUTANEOUS LEISHMANIASIS, Transactions of the Royal Society of Tropical Medicine and Hygiene, 88(2), 1994, pp. 223-225
Citations number
18
Categorie Soggetti
Public, Environmental & Occupation Heath","Tropical Medicine
Journal title
Transactions of the Royal Society of Tropical Medicine and Hygiene → ACNP
ISSN journal
00359203
Volume
88
Issue
2
Year of publication
1994
Pages
223 - 225
Database
ISI
SICI code
0035-9203(1994)88:2<223:AOFTTO>2.0.ZU;2-6
Abstract
A 15% aminosidine sulphate (AS)/10% urea/white soft paraffin (WSP) oin tment cured all Leishmania major lesions on Balb/C mice following topi cal application for 10 d. Some relapses were observed 10 weeks after t reatment. AS alone in WSP ointment was also highly effective. The oint ment containing urea was non-irritant to mice, whereas ointments conta ining quaternary ammonium compounds were irritant. The 15% AS/10% urea /WSP ointment was not effective in the treatment of L. mexicana or L. panamensis lesions on Balb/C mice, no cure being observed.