In 134 cervical explorations for hyperparathyroidism, methylene blue w
as administered intraoperatively to stain parathyroid glands. Seventy-
seven out of 79 adenomas (97.5%) and 199 out of 204 hyperplastic gland
s (97.6%) were clearly stained. The only recurrences were observed in
patients undergoing surgery for hyperplasia of the parathyroid glands.
The recurrences (12%) were mainly due either to initial wrong diagnos
is of parathyroid adenoma, or they were graft dependent. Methylene blu
e is an effective, safe and easy way to localize and identify abnormal
parathyroid glands, thereby improving the results and shortening the
operating time.